INBDE (Integrated National Board Dental Examination) Practice Exam

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Which two interleukins are anti-inflammatory?

  1. IL-4 and IL-10

  2. IL-1 and IL-6

  3. IFN-gamma and TNFa

  4. IL-2 and IL-7

The correct answer is: IL-4 and IL-10

IL-4 and IL-10 are considered anti-inflammatory interleukins. IL-4 helps in the differentiation of naive helper T cells into Th2 cells, which are involved in the regulation of the immune response and inflammation. IL-10 is known for its anti-inflammatory properties as it inhibits the production of pro-inflammatory cytokines. These interleukins play a crucial role in dampening the inflammatory response and promoting immune tolerance. The other options are incorrect because: - IL-1 and IL-6 (Option B) are pro-inflammatory interleukins that promote inflammation and immune responses. - IFN-gamma and TNFa (Option C) are also pro-inflammatory cytokines that play a role in inflammation and immune responses. - IL-2 and IL-7 (Option D) are not typically considered anti-inflammatory interleukins; they have various functions in immune responses but are not specifically known for their anti-inflammatory properties.