INBDE (Integrated National Board Dental Examination) Practice Exam

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Which condition is associated with autoantibodies against desmosomes and a positive Nikolsky's sign?

Wegener's Granulomatosis
Pemphigoid
MEN 2B
Pemphigus

The correct answer is: Pemphigus

Pemphigus is the correct answer because it is a condition associated with autoantibodies against desmosomes and a positive Nikolsky's sign. In pemphigus, the immune system produces antibodies that target desmosomal proteins, leading to the breakdown of intercellular connections in the skin and mucous membranes. This results in the characteristic clinical finding of a positive Nikolsky's sign, which is the ability to induce blistering or sloughing of the skin or mucosa by applying lateral pressure. Options A and B, Wegener's Granulomatosis and Pemphigoid, are not associated with autoantibodies against desmosomes or a positive Nikolsky's sign. Option C, MEN 2B, is a genetic disorder associated with multiple endocrine neoplasia and has no direct association with desmosomes or Nikolsky's sign.