Which biopsy is appropriate for a large specimen (> 1cm) presumed malignant?

The appropriate biopsy for a larger specimen that is suspected to be malignant would be an incisional biopsy. This type of biopsy involves surgically removing a small part of the tumor or tissue for examination. Cytology involves studying individual cells, whereas aspiration involves extracting fluid from a mass. Excisional biopsy involves removing the entire tumor or tissue, which may not be necessary or desired for a larger specimen.