INBDE (Integrated National Board Dental Examination) Practice Exam

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What syndrome is characterized by polyostotic fibrous dysplasia, cutaneous cafe de lait spots, and endocrine abnormalities?

  1. Gardner's syndrome

  2. Hyperparathyroidism

  3. Paget's disease

  4. McCune-Albright syndrome

The correct answer is: McCune-Albright syndrome

McCune-Albright syndrome is the correct answer. This syndrome is characterized by the triad of polyostotic fibrous dysplasia (resulting in bone deformities and fractures), cutaneous cafe-au-lait spots (pigmented skin lesions), and multiple endocrine abnormalities such as precocious puberty, hyperthyroidism, and Cushing syndrome. Gardner's syndrome is characterized by the presence of multiple colorectal adenomatous polyps along with extracolonic manifestations such as osteomas and soft tissue tumors. Hyperparathyroidism is characterized by excessive production of parathyroid hormone leading to hypercalcemia and can be primary, secondary, or tertiary. Paget's disease is characterized by abnormal bone remodeling, leading to enlarged and deformed bones which can cause pain, fractures, and arthritis-like symptoms.