INBDE (Integrated National Board Dental Examination) Practice Exam

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What pro inflammatory mediator is known for bone resorption?

IL-1
IL-6
IL-4
TNFa

The correct answer is: IL-1

IL-1, or Interleukin-1, is the correct answer. IL-1 is a pro-inflammatory mediator that plays a key role in bone resorption. It stimulates osteoclast activity, leading to the breakdown of bone tissue. This process is important for normal bone remodeling but can become problematic when dysregulated, such as in conditions like periodontal disease where excessive bone resorption can occur. IL-6, IL-4, and TNF-alpha are also pro-inflammatory mediators, but they are not specifically known for their role in bone resorption. IL-6 plays a role in the acute phase response and immune regulation, IL-4 is involved in the regulation of the immune response, and TNF-alpha has various roles in inflammation and immune response. However, IL-1 is the primary mediator associated with bone resorption in this context.