INBDE (Integrated National Board Dental Examination) Practice Exam

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Ace your INBDE with our comprehensive practice exam. Featuring detailed explanations, interactive flashcards, and a wide array of multiple-choice questions designed to mirror the real test. Get ready to surpass your expectations!

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What is the most important proteinase involved in the destruction of periodontal tissues, which can be inhibited by tetracyclines?

MMP-3
MMP-8
Collagenase
Hyaluronidase

The correct answer is: MMP-8

MMP-8, also known as collagenase-2, is the most important proteinase involved in the destruction of periodontal tissues. MMP-8 specifically targets collagen, which is a major component of the periodontal ligament and the extracellular matrix surrounding the teeth. Tetracyclines can inhibit MMP-8 activity, which is one of the reasons they have been used in the treatment of periodontal disease. MMP-3 (stromelysin), collagenase, and hyaluronidase are also involved in tissue destruction, but they are not as specifically associated with periodontal tissue destruction as MMP-8.