INBDE (Integrated National Board Dental Examination) Practice Exam

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Ace your INBDE with our comprehensive practice exam. Featuring detailed explanations, interactive flashcards, and a wide array of multiple-choice questions designed to mirror the real test. Get ready to surpass your expectations!

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What is the mechanism of action (MOA) of NSAIDs?

Increase prostaglandin synthesis
Inhibit prostaglandin synthesis via inhibiting COX 1 and COX 2
Activate osteoclasts
Suppress immune response

The correct answer is: Inhibit prostaglandin synthesis via inhibiting COX 1 and COX 2

NSAIDs, or nonsteroidal anti-inflammatory drugs, work by inhibiting the activity of cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2. These enzymes play a key role in the production of prostaglandins, which are responsible for causing pain, inflammation, and fever. By inhibiting COX enzymes, NSAIDs reduce the production of prostaglandins, resulting in decreased pain and inflammation. Option A is incorrect because it states that NSAIDs increase prostaglandin synthesis, which is the opposite of their MOA. Option C is incorrect because it refers to the activation of osteoclasts, which are involved in bone metabolism and have no role in the mechanism of action of NSAIDs. Option D is incorrect because while NSAIDs have some effect on suppressing the immune response, it is not their primary mechanism of action.