INBDE (Integrated National Board Dental Examination) Practice Exam

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What is the mechanism of action (MOA) for bisphosphonates?

Stimulates osteoblasts
Inhibits osteoclasts
Activates COX enzymes
Promotes enamel repair

The correct answer is: Inhibits osteoclasts

Bisphosphonates are a class of drugs used to prevent and treat conditions related to bone loss, such as osteoporosis. The mechanism of action (MOA) for bisphosphonates is by inhibiting osteoclasts, which are cells responsible for breaking down and resorbing old bone tissue. By inhibiting these cells, bisphosphonates can prevent further bone loss and promote bone density. Options A, C, and D are incorrect because they do not involve the regulation of osteoclasts, and are not directly related to the MOA of bisphosphonates.