INBDE (Integrated National Board Dental Examination) Practice Exam

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The combination of freckles and intestinal polyps is a hallmark of which syndrome?

  1. Cushing's syndrome

  2. Down syndrome

  3. Peutz-Jeghers syndrome

  4. Gardner's syndrome

The correct answer is: Peutz-Jeghers syndrome

Peutz-Jeghers syndrome is the only option that specifically mentions freckles and intestinal polyps as a hallmark of the syndrome. Cushing's syndrome is associated with weight gain and high levels of cortisol, not freckles and polyps. Down syndrome is a genetic condition that results in physical and intellectual disabilities, but does not typically involve freckles or intestinal polyps. Gardner's syndrome primarily affects the colon and can lead to colon cancer, but it is not associated with freckles. Thus, the combination of freckles and intestinal polyps is a key distinguishing factor for Peutz-Jeghers syndrome.