INBDE (Integrated National Board Dental Examination) Practice Exam

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Polymorphisms in which genes have been associated with severe chronic periodontitis?

  1. iL-1

  2. iL-6

  3. TNF-alpha

  4. iL-10

The correct answer is: iL-1

Polymorphisms in genes refer to variations in a gene's DNA sequence that can lead to different physical characteristics or traits. In this question, we are specifically looking for which gene has been associated with severe chronic periodontitis. Choices B, C, and D (iL-6, TNF-alpha, and iL-10) are all cytokines, which are signaling molecules that can affect the immune response. While these cytokines may play a role in periodontitis, current research suggests that polymorphisms in the iL-1 gene are strongly associated with the development and progression of this condition. Therefore, A is the correct answer because it specifically addresses the gene in question.

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