INBDE (Integrated National Board Dental Examination) Practice Exam

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Collagen destruction is mediated through what pro inflammatory mediator?

  1. MMPs

  2. IL-1

  3. IFN-gamma

  4. TNFa

The correct answer is: MMPs

Collagen destruction is primarily mediated through Matrix Metalloproteinases (MMPs). MMPs are enzymes that play a crucial role in the breakdown of the extracellular matrix, including collagen. These enzymes are key players in the process of tissue remodeling and repair, but when overexpressed or dysregulated, they can lead to excessive collagen degradation, as seen in conditions such as periodontal disease. While the other pro-inflammatory mediators listed - IL-1, IFN-gamma, and TNF-alpha - do play important roles in the inflammatory response, they are not primarily responsible for the direct degradation of collagen as MMPs are.

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